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Article

Melancholic features and typical neurovegetative symptoms of major depressive disorder show specific polygenic patterns.

Journal of affective disorders - 1 Jan 2023

Oliva Vincenzo, Fanelli Giuseppe, Kasper Siegfried, Zohar Joseph, Souery Daniel, Montgomery Stuart, Albani Diego, Forloni Gianluigi, Ferentinos Panagiotis, Rujescu Dan, Mendlewicz Julien, De Ronchi Diana, Fabbri Chiara, Serretti Alessandro

Abstract excerpt

BACKGROUND: Major depressive disorder (MDD) is a highly prevalent psychiatric condition characterised by a heterogeneous clinical presentation and an estimated twin-based heritability of ~40-50 %. Different clinical MDD subtypes might partly reflect distinctive underlying genetics. This study aims to investigate if polygenic risk scores (PRSs) for different psychiatric disorders, personality traits, and substance...

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PMID: 36216191
DOI: 10.1016/j.jad.2022.10.003

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