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Article

Unbiased metabolome screen links serum urate to risk of Alzheimer's disease.

Neurobiology of aging - 1 Dec 2022

Şanlı Beyazıt Abdurrahman, Whittaker Katherine J, Motsi Gamuchirai K, Shen Emery, Julian Thomas H, Cooper-Knock Johnathan

Abstract excerpt

Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disease caused by a combination of genetic and environmental risk factors. The serum metabolome refers to a set of small-molecules which are an important determinant of cellular health. We obtained genome-wide association study (GWAS) summary statistics for serum concentrations of 376 metabolites which were population matched with 2 GWAS...

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PMID: 36206691
DOI: 10.1016/j.neurobiolaging.2022.09.004

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