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Article

Causal relationship between metabolites, cerebral volume, and amyotrophic lateral sclerosis: A 2-step Mendelian randomization analysis.

Medicine - 18 Sept 2026

Liu Youjia, Chen Sihui, Wu Yanyun, Zhou Wenting, Shang Huifang, Ou Ruwei

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by motor neuron degeneration. Although metabolic abnormalities have been implicated in ALS, the causal relationships between circulating metabolites and ALS remain unclear. This study aimed to investigate the potential causal associations between plasma metabolites and ALS risk and to explore the mediating role of...

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Topics

Amyotrophic Lateral Sclerosis
Humans
Mendelian Randomization Analysis
Genome-Wide Association Study
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42760704
DOI: 10.1097/MD.0000000000050769
PMCID: PMC13593307

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