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Article

Unbiased metabolome screen leads to personalized medicine strategy for amyotrophic lateral sclerosis

1 Mar 2022

Abstract excerpt

Abstract Amyotrophic lateral sclerosis is a rapidly progressive neurodegenerative disease that affects 1/350 individuals in the United Kingdom. The cause of amyotrophic lateral sclerosis is unknown in the majority of cases. Two-sample Mendelian randomization enables causal inference between an exposure, such as the serum concentration of a specific metabolite, and disease risk. We obtained genome-wide association...

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PMID: 35441136
DOI: 10.1093/braincomms/fcac069

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