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Risk of Alzheimer's disease and genetically predicted levels of 1400 plasma metabolites: a Mendelian randomization study.

Scientific reports - 30 Oct 2024

Cao Di, Zhang Yini, Zhang Shaobo, Li Jun, Yang Qiguang, Wang Ping

Abstract excerpt

Alzheimer's disease (AD) is a metabolic disorder. Discovering the metabolic products involved in the development of AD may help not only in the early detection and prevention of AD but also in understanding its pathogenesis and treatment. This study investigated the causal association between the latest large-scale plasma metabolites (1091 metabolites and 309 metabolite ratios) and AD. Through the application of...

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Alzheimer Disease
Genetic Predisposition to Disease
Mendelian Randomization Analysis
Metabolome
Metabolomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 39478193
DOI: 10.1038/s41598-024-77921-6
PMCID: PMC11525545

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