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Causal Association between Circulating Metabolites and Dementia: A Mendelian Randomization Study

28 Aug 2024

Abstract excerpt

The causal association of circulating metabolites with dementia remains uncertain. We assessed the causal association of circulating metabolites with dementia utilizing Mendelian randomization (MR) methods. We performed univariable MR analysis to evaluate the associations of 486 metabolites with dementia, Alzheimer's disease (AD), and vascular dementia (VaD) risk. For secondary validation, we replicated the...

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PMID: 39275195
DOI: 10.3390/nu16172879

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