Article
A germline SNP in BRMS1 predisposes patients with lung adenocarcinoma to metastasis and can be ameliorated by targeting c-fos.
Science translational medicine - 5 Oct 2022
Liu Yuan, Chudgar Neel, Mastrogiacomo Brooke, He Di, Lankadasari Manendra B, Bapat Samhita, Jones Gregory D, Sanchez-Vega Francisco, Tan Kay See, Schultz Nikolaus, Mukherjee Semanti, Offit Kenneth, Bao Yongde, Bott Matthew J, Rekhtman Natasha, Adusumilli Prasad S, Li Bob T, Mayo Marty W, Jones David R
Abstract excerpt
About 50% of patients with early-stage, surgically resected lung cancer will develop distant metastasis. There remains an unmet need to identify patients likely to develop recurrence and to design innovative therapies to decrease this risk. Two primary isoforms of BRMS1, v1 and v2, are present in humans. Using next-generation sequencing of BRMS1 on matched human noncancerous lung tissue and non-small cell lung...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.