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Article

Brain metastases lung adenocarcinoma patients with BRG1 loss have a grim prognosis, featuring unique morphological and methylation characteristics.

Clinical & experimental metastasis - 21 Mar 2025

Yang Junjie, Feng Jing, Duan Zejun, Liu Xing, Zhang Hongwei, Zhang Mingshan, Ma Zhong, Hu Zejuan, Xiang Lei, Qi Xueling

Abstract excerpt

BRG1 deficiency in patients with lung adenocarcinoma that has metastasized to the brain, termed BRG1-deficient brain metastasis lung adenocarcinoma, is an uncommon event. Prior to this study, these patients had not undergone extensive molecular and (epi)genetic analysis. We report a comprehensive clinical, histopathologic, and molecular assessment of 9 BRG1-deficient brain metastasis lung adenocarcinoma cohort...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40116987
DOI: 10.1007/s10585-025-10337-2
PMCID: PMC11928351

Genes

SMARCA4
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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