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Article

Whole-exome and RNA sequencing of pulmonary carcinoid reveals chromosomal rearrangements associated with recurrence.

Lung cancer (Amsterdam, Netherlands) - 1 Jul 2020

Miyanaga Akihiko, Masuda Mari, Motoi Noriko, Tsuta Koji, Nakamura Yuka, Nishijima Nobuhiko, Watanabe Shun-Ichi, Asamura Hisao, Tsuchida Akihiko, Seike Masahiro, Gemma Akihiko, Yamada Tesshi

Abstract excerpt

INTRODUCTION: The majority of pulmonary carcinoid (PC) tumors can be cured by surgical resection alone, but a significant proportion of patients experience recurrence. As PC is insensitive to conventional chemotherapy, further clarification of the molecular mechanisms of metastasis is needed in order to develop targeted therapeutics. METHODS: We performed comprehensive whole-exome sequencing (WES) of primary...

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Calcium-Calmodulin-Dependent Protein Kinases
Carcinoid Tumor
Exome
Exome Sequencing
Lung Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Recurrence, Local

Sequence Analysis, RNA

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PMID: 32417679
DOI: 10.1016/j.lungcan.2020.03.027

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