Whole-exome sequencing identifies somatic mutations associated with lung cancer metastasis to the brain

Abstract excerpt

Background: Lung cancer is the most aggressive cancer, resulting in one-quarter of all cancer-related deaths, and its metastatic spread accounts for >70% of these deaths, especially metastasis to the brain. Metastasis-associated mutations are important biomarkers for metastasis prediction and outcome improvement.Methods: In this study, we applied whole-exome sequencing (WES) to identify potential...

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