Article
Genomic characterization of human brain metastases identifies drivers of metastatic lung adenocarcinoma.
Nature genetics - 1 Apr 2020
Shih David J H, Nayyar Naema, Bihun Ivanna, Dagogo-Jack Ibiayi, Gill Corey M, Aquilanti Elisa, Bertalan Mia, Kaplan Alexander, D'Andrea Megan R, Chukwueke Ugonma, Ippen Franziska Maria, Alvarez-Breckenridge Christopher, Camarda Nicholas D, Lastrapes Matthew, McCabe Devin, Kuter Ben, Kaufman Benjamin, Strickland Matthew R, Martinez-Gutierrez Juan Carlos, Nagabhushan Deepika, De Sauvage Magali, White Michael D, Castro Brandyn A, Hoang Kaitlin, Kaneb Andrew, Batchelor Emily D, Paek Sun Ha, Park Sun Hye, Martinez-Lage Maria, Berghoff Anna S, Merrill Parker, Gerstner Elizabeth R, Batchelor Tracy T, Frosch Matthew P, Frazier Ryan P, Borger Darrell R, Iafrate A John, Johnson Bruce E, Santagata Sandro, Preusser Matthias, Cahill Daniel P, Carter Scott L, Brastianos Priscilla K
Abstract excerpt
Brain metastases from lung adenocarcinoma (BM-LUAD) frequently cause patient mortality. To identify genomic alterations that promote brain metastases, we performed whole-exome sequencing of 73 BM-LUAD cases. Using case-control analyses, we discovered candidate drivers of brain metastasis by identifying genes with more frequent copy-number aberrations in BM-LUAD compared to 503 primary LUADs. We identified three...
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