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Article

Identification of TUBB8 Variants in 5 Primary Infertile Women with Multiple Phenotypes in Oocytes and Early Embryos.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Apr 2023

Yu Wenzhu, Zhang Shaodi, Yin Baoli, Dong Chang, Zhang Victor Wei, Zhang Cuilian

Abstract excerpt

Tubulin beta 8 class VIII (TUBB8) is a β-tubulin isotype that is specifically expressed in human oocytes and early embryos. It has been identified as a disease-causing gene in primary female infertility by affecting oocyte maturation arrest. This study investigated the genetic cause of female infertility in five patients from four families. Five women with primary infertility were recruited. Medical-exome...

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Identifiers

PMID: 36197634
DOI: 10.1007/s43032-022-01079-7
PMCID: PMC10159944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of TUBB8 Variants in 5 Primary Infertile Women with Multiple Phenotypes in Oocytes and Early Embryos.PMID 36197634Read ↗

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Novel mutations and structural deletions in TUBB8: expanding mutational and phenotypic spectrum of patients with arrest in oocyte maturation, fertilization or early embryonic development.Semantic proximity Read ↗

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