Article
Mutation analysis of tubulin beta 8 class VIII in infertile females with oocyte or embryonic defects.
Clinical genetics - 1 Jan 2021
Yang Ping, Yin Changjian, Li Mei, Ma Shuiying, Cao Yongzhi, Zhang Changming, Chen Tailai, Zhao Han
Abstract excerpt
Variants of tubulin beta 8 class VIII (TUBB8) have been shown to be associated with female infertility characterized by oocyte or embryonic defects. To further investigate the mutational spectrum of TUBB8 and the prevalence of variants, we performed Sanger sequencing of TUBB8 on a total of 115 infertile females who had undergone repeated in vitro fertilization cycles with oocyte or embryonic defects and 200...
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