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Article

Mutation analysis of the TUBB8 gene in primary infertile women with oocyte maturation arrest.

Journal of ovarian research - 30 Mar 2022

Yao Zhongyuan, Zeng Jun, Zhu Huimin, Zhao Jing, Wang Xiaoxia, Xia Qiuping, Li Yanping, Wu Lingqian

Abstract excerpt

BACKGROUND: Oocyte maturation arrest at metaphase I leads to fertilization failure in humans. In early embryos, the tubulin beta 8 class VIII (TUBB8) encodes a β-tubulin isotype and aids in the assembling of the human oocyte spindle. Mutations in the TUBB8 potentially interfere with human oocyte maturation-a crucial prerequisite for fertilization and subsequent embryonic development. This study aims to...

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Identifiers

PMID: 35354490
DOI: 10.1186/s13048-022-00971-9
PMCID: PMC8969352

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Mutation analysis of the TUBB8 gene in primary infertile women with oocyte maturation arrest.PMID 35354490Read ↗

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Mutation analysis of tubulin beta 8 class VIII in infertile females with oocyte or embryonic defects.Semantic proximity Read ↗

Two mutations in TUBB8 cause developmental arrest in human oocytes and early embryos.Semantic proximity Read ↗

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