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Article

Expanding the Genetic and Phenotypic Spectrum of Female Infertility Caused by TUBB8 Mutations.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Dec 2021

Lu Qianneng, Zhang Xiaolan, Cao Qiqi, Wang Congjing, Ding Jie, Zhao Chun, Zhang Junqiang, Ling Xiufeng, Meng Qingxia, Huo Ran, Li Hong

Abstract excerpt

Tubulin beta eight class VIII (TUBB8) is a subtype of β-tubulin that only exists in primates. TUBB8 mutations have been reported to cause arrest of oocyte maturation and embryonic development. We aim to further investigate the mutational spectrum of TUBB8 and its relevance with female infertility. In our study, infertile patients were recruited, and their basal and clinical characteristics were analyzed. Genomic...

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Source

Identifiers

PMID: 34494234
DOI: 10.1007/s43032-021-00694-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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