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Three Novel Mutations in TUBB8 Cause Female Infertility Due to Multiple Morphological Abnormalities of the Oocyte and Early Embryo.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Jun 2025

Li Duan, Yuan Guanghui, Wang Xiaoxiao, Zhuang Jiao, Wang Lie, Liu Yingxue, Liu Xiaowen, Han Linfang, Dou Huaiqian, Li Bing, Hao Cuifang

Abstract excerpt

Recent years have seen a global increase in infertility, affecting up to 17.5% of the population. For successful human reproduction, the proper development process of the oocyte, fertilization, and early embryo is required. Assisted reproductive technology (ART), which is the primary treatment for infertility, uses the morphology of oocytes and zygotes as parameters to predict ART outcomes. However, factors such...

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Embryonic Development
Infertility, Female
Mutation
Mutation, Missense
Oocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40246784
DOI: 10.1007/s43032-025-01844-4

Genes

TUBB8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Three Novel Mutations in TUBB8 Cause Female Infertility Due to Multiple Morphological Abnormalities of the Oocyte and Early Embryo.PMID 40246784Read ↗

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Novel mutations in TUBB8 expand the mutational and phenotypic spectrum of patients with zygotes containing multiple pronuclei.Semantic proximity Read ↗

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TUBB8 Mutations Cause Female Infertility with Large Polar Body Oocyte and Fertilization FailureSemantic proximity Read ↗

Two mutations in TUBB8 cause developmental arrest in human oocytes and early embryos.Semantic proximity Read ↗

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