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Article

Dexmedetomidine protects cells from Angiotensin II-induced smooth muscle cell phenotype switch and endothelial cell dysfunction.

Cell cycle (Georgetown, Tex.) - 1 Feb 2023

Dai Min, Zhu Xiaohong, Zeng Simin, Liu Qiang, Hu Ruilin, Huang Lianghui, Wang Yu, Deng Jun, Yu Qi

Abstract excerpt

Abdominal aortic aneurysm (AAA) is a vascular disorder greatly threatening life of the elderly population. Dexmedetomidine (DEX), an α2-adrenergic receptor agonist, has been shown to suppress AAA development. Nevertheless, the signaling pathways that might be mediated by DEX in AAA has not been clarified. Vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) were treated with Angiotensin II (Ang II) to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36196460
DOI: 10.1080/15384101.2022.2124489
PMCID: PMC9879174

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