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Bedaquiline resistant Mycobacterium tuberculosis clinical isolates with and without rv0678 mutations have similar growth patterns under varying BDQ drug pressure.

Tuberculosis (Edinburgh, Scotland) - 1 Dec 2022

Saeed Dania Khalid, Ashraf Javaria, Hasan Zahra, Shakoor Sadia, Kanji Akbar, Hasan Rumina

Abstract excerpt

Resistance associated mutations have been reported to alter the growth of Mycobacterium tuberculosis (MTB) isolates under drug pressure. However, there is little information on the growth characteristics of bedaquiline (BDQ) resistant isolates in the presence of BDQ. To further understand the role of rv0678, we aimed to study whether the presence of rv0678 variants in BDQ resistant isolates alters the killing...

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PMID: 36195000
DOI: 10.1016/j.tube.2022.102266

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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