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Phenotypic drug susceptibility testing and genotypic characterization of Bedaquiline resistance in drug resistant Mycobacteriumtuberculosis.

Indian journal of medical microbiology - 1 Jan 2026

Victor Annie Sheeba, V Manigandan, Ninan Marilyn Mary, Gupta Richa, Frederick Asha, Ramachandran Ranjani, Rebekah Grace, Michael Joy Sarojini

Abstract excerpt

PURPOSE: The new drugs bedaquiline, delamanid, and pretomanid have been approved for treating drug-resistant tuberculosis. The World Health Organization currently recommends the BPaL(M) regimen, which lasts 6-9 months, for managing drug-resistant tuberculosis. This study aimed to perform phenotypic drug susceptibility testing and identify mutations linked to bedaquiline resistance through whole genome sequencing....

Topics

Diarylquinolines
Humans
Mycobacterium tuberculosis
Antitubercular Agents
Microbial Sensitivity Tests
Genotype
India
Tuberculosis, Multidrug-Resistant
Prospective Studies
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Whole Genome Sequencing

Phenotype

Drug Resistance, Bacterial

Source

Identifiers

PMID: 42276191
DOI: 10.1016/j.ijmmb.2026.101163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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