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The importance of heteroresistance and efflux pumps in bedaquiline-resistant Mycobacterium tuberculosis isolates from Iran.

Annals of clinical microbiology and antimicrobials - 25 Apr 2024

Madadi-Goli Nahid, Ahmadi Kamal, Kamakoli Mansour Kargarpour, Azizi Mohsen, Khanipour Sharareh, Dizaji Shahin Pourazar, Nasehi Mahshid, Siadat Seyed Davar, Fateh Abolfazl, Vaziri Farzam

Abstract excerpt

BACKGROUND: Tuberculosis (TB) continues to pose a threat to communities worldwide and remains a significant public health issue in several countries. We assessed the role of heteroresistance and efflux pumps in bedaquiline (BDQ)-resistant Mycobacterium tuberculosis isolates. METHODS: Nineteen clinical isolates were included in the study, of which fifteen isolates were classified as MDR or XDR, while four isolates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38664815
DOI: 10.1186/s12941-024-00694-3
PMCID: PMC11046812

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