Article
Variants associated with Bedaquiline (BDQ) resistance identified in Rv0678 and efflux pump genes in Mycobacterium tuberculosis isolates from BDQ naïve TB patients in Pakistan.
BMC microbiology - 25 Feb 2022
Saeed Dania Khalid, Shakoor Sadia, Razzak Safina Abdul, Hasan Zahra, Sabzwari Saba Faraz, Azizullah Zahida, Kanji Akbar, Nasir Asghar, Shafiq Samreen, Ghanchi Najia Karim, Hasan Rumina
Abstract excerpt
BACKGROUND: Mutations in the Rv0678, pepQ and atpE genes of Mycobacterium tuberculosis (MTB) have been reported to be associated with reduced antimycobacterial susceptibility to bedaquiline (BDQ). Resistance conferring mutations in treatment naïve MTB strains is likely to have implications for BDQ based new drug regimen that aim to shorten treatment duration. We therefore investigated the genetic basis of...
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