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Article

Acquired resistance of Mycobacterium tuberculosis to bedaquiline.

PloS one - 1 Jan 2014

Andries Koen, Villellas Cristina, Coeck Nele, Thys Kim, Gevers Tom, Vranckx Luc, Lounis Nacer, de Jong Bouke C, Koul Anil

Abstract excerpt

Bedaquiline (BDQ), an ATP synthase inhibitor, is the first drug to be approved for treatment of multi-drug resistant tuberculosis in decades. In vitro resistance to BDQ was previously shown to be due to target-based mutations. Here we report that non-target based resistance to BDQ, and cross-resistance to clofazimine (CFZ), is due to mutations in Rv0678, a transcriptional repressor of the genes encoding the...

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Identifiers

PMID: 25010492
DOI: 10.1371/journal.pone.0102135
PMCID: PMC4092087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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