Article
Whole Genome Sequencing Identifies Novel Mutations Associated With Bedaquiline Resistance in Mycobacterium tuberculosis.
Frontiers in cellular and infection microbiology - 1 Jan 2022
Guo Qinglong, Bi Jing, Lin Qiao, Ye Taosheng, Wang Zhongyuan, Wang Zhaoqin, Liu Lei, Zhang Guoliang
Abstract excerpt
Bedaquiline (BDQ), a new antitubercular agent, has been used to treat drug-resistant tuberculosis (TB). Although mutations in atpE, rv0678, and pepQ confer major resistance to BDQ, the mechanisms of resistance to BDQ in vitro and in clinical settings have not been fully elucidated. We selected BDQ-resistant mutants from 7H10 agar plates containing 0.5 mg/L BDQ (the critical concentration) and identified mutations...
Topics
- Antitubercular Agents
- Diarylquinolines
- Humans
- Microbial Sensitivity Tests
- Mutation
- Mycobacterium tuberculosis
- Tuberculosis, Lymph Node
- Whole Genome Sequencing