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Article

Reduced susceptibility and resistance to bedaquiline in clinical M. tuberculosis isolates.

The Journal of infection - 1 May 2020

Peretokina Irina V, Krylova Ludmila Yu, Antonova Olga V, Kholina Margarita S, Kulagina Elena V, Nosova Elena Yu, Safonova Svetlana G, Borisov Sergey E, Zimenkov Danila V

Abstract excerpt

OBJECTIVES: Bedaquiline is an effective drug used to treat MDR and XDR tuberculosis, providing high cure rates in complex therapy. Mutations in the mmpR (rv0678) and atpE genes are associated with reduced susceptibility to bedaquiline and have been identified in both in vitro selected strains and clinical isolates. However, the phenotypic criteria used to detect bedaquiline resistance have yet to be established...

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PMID: 31981638
DOI: 10.1016/j.jinf.2020.01.007

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