Temperament traits mediate the relationship between CACNA1C polymorphisms and bipolar disorder in cisgender women.

doi:10.1007/s00406-022-01493-7

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Temperament traits mediate the relationship between CACNA1C polymorphisms and bipolar disorder in cisgender women.

European archives of psychiatry and clinical neuroscience - 1 Feb 2023

Bastos Clarissa Ribeiro, Bock Bertha Bueno, Xavier Janaina, Camerini Laísa, Dewes Samantha Seibt, Grellert Mateus, de Carvalho Hudson Wander, Jansen Karen, da Silva Ricardo Azevedo, Pinheiro Ricardo Tavares, de Mattos Souza Luciano, Oses Jean Pierre, Portela Luis Valmor, Lara Diogo Rizzato, Tovo-Rodrigues Luciana, Ghisleni Gabriele

Abstract excerpt

The influence of temperament traits on bipolar disorder (BD) has been investigated. Both temperament traits and BD are partially genetically determined and seem to be influenced by variations in the CACNA1C gene. These variations presented a significant interactive effect with biological sex, although studies that evaluate this relationship are scarce. Here, we assessed the mediation effect of temperament traits...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bipolar Disorder

Share to Calcium Channels, L-Type

Share to Cross-Sectional Studies

Share to Emotions

Share to Polymorphism, Single Nucleotide

Share to Temperament

Share to Young Adult

Source

Open in PubMed

Identifiers

PMID: 36181558
DOI: 10.1007/s00406-022-01493-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Temperament traits mediate the relationship between CACNA1C polymorphisms and bipolar disorder in cisgender women.PMID 36181558Read ↗

The role of CACNA1C gene and childhood trauma interaction on bipolar disorder.Semantic proximity Read ↗

The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general population.Semantic proximity Read ↗

Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci.Semantic proximity Read ↗

The theoretical underpinnings of affective temperaments: implications for evolutionary foundations of bipolar disorder and human nature.Semantic proximity Read ↗

Heritability and genome-wide SNP linkage analysis of temperament in bipolar disorder.Semantic proximity Read ↗

Association of genetic variation in CACNA1C with bipolar disorder in Han Chinese.Semantic proximity Read ↗

Exploring the associations between genetic variants in genes encoding for subunits of calcium channel and subtypes of bipolar disorder.Semantic proximity Read ↗

The Role of Temperament in the Etiopathogenesis of Bipolar Spectrum Illness.Semantic proximity Read ↗

Differential analysis of CACNA1C polymorphisms among patients with depression and bipolar disorder and exploration of sleep as a mediator.Semantic proximity Read ↗

Personality endophenotypes for bipolar affective disorder: a family-based genetic association analysis.Semantic proximity Read ↗

CACNA1C hypermethylation is associated with bipolar disorder.Semantic proximity Read ↗

Initial evidence for the role of CACNA1C on subcortical brain morphology in patients with bipolar disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.