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Article

Differential analysis of CACNA1C polymorphisms among patients with depression and bipolar disorder and exploration of sleep as a mediator.

Journal of affective disorders - 1 Nov 2026

Xu Zhi, Guo Yang, Shao Yongqi, Shen Tian, Chen Lei, Chen Zimu, Chen Suzhen, Chen Bingwei, Yuan Yonggui, Cai Yang

Abstract excerpt

BACKGROUND: Differentiating the depressive phase of bipolar disorder (BD) from major depressive disorder (MDD) remains a significant clinical challenge. As CACNA1C is a prominent susceptibility gene for BD across diverse populations, this study evaluated the utility of its polymorphisms, combined with clinical risk factors, in distinguishing BD from MDD, while investigating the potential mediating role of sleep...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42349525
DOI: 10.1016/j.jad.2026.122152

Genes

CACNA1C

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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