Article
The role of CACNA1C gene and childhood trauma interaction on bipolar disorder.
Progress in neuro-psychopharmacology & biological psychiatry - 13 Jul 2020
Bastos Clarissa Ribeiro, Tovo-Rodrigues Luciana, Ardais Ana Paula, Xavier Janaina, Salerno Pamela Silva Vitória, Camerini Laísa, Jansen Karen, de Mattos Souza Luciano Dias, da Silva Ricardo Azevedo, Lara Diogo Rizzato, Ghisleni Gabriele
Abstract excerpt
Studies on gene x environment interaction (GxE) have provided vital information for uncovering the origins of complex diseases. When considering the etiology of bipolar disorder (BD), the role of such interactions is unknown. Here, we tested whether trauma during childhood could modify the effect of two polymorphisms in the CACNA1C gene (rs1006737 and rs4765913) in terms of susceptibility to BD. The study...
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