Article
Heritability and genome-wide SNP linkage analysis of temperament in bipolar disorder.
Journal of affective disorders - 25 Sept 2013
Greenwood Tiffany A, Badner Judith A, Byerley William, Keck Paul E, McElroy Susan L, Remick Ronald A, Sadovnick A Dessa, Akiskal Hagop S, Kelsoe John R
Abstract excerpt
BACKGROUND: The many attempts to identify genes for bipolar disorder (BD) have met with limited success, which has generally been attributed to genetic heterogeneity and small gene effects. However, it is also possible that the categorical phenotypes used in genetic studies of BD are not the most informative or biologically relevant. We have explored aspects of temperament as quantitative phenotypes for BD...
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