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Article

Alterations in p53 Influence hTERT, VEGF and MMPs Expression in Oral Cancer Patients.

Asian Pacific journal of cancer prevention : APJCP - 1 Sept 2022

Singh Ragini D, Patel Kinjal A, Patel Jayendra B, Patel Prabhudas S

Abstract excerpt

BACKGROUND: Mutant p53 is the crucial molecule in the etiopathogenesis of oral cancer. Therefore, we aimed to evaluate the impact of alterations of the p53 gene and its negative feedback regulator, MDM2, on the expression of hTERT, VEGF, and MMPs; the critical genes involved in oral cancer progression. MATERIAL AND METHODS: p53 and MDM2 genotyping were done by PCR-RFLP. p53 mutation analysis was performed using...

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Source

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Identifiers

PMID: 36172677
DOI: 10.31557/APJCP.2022.23.9.3141
PMCID: PMC9810300

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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