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Article

MDM2 SNP 309 and p53 codon 72 polymorphisms are associated with the outcome of oral carcinoma patients receiving postoperative irradiation.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 May 2008

Tu Hsi-Feng, Chen Hong-Wen, Kao Shou-Yen, Lin Shu-Chun, Liu Chung-Ji, Chang Kuo-Wei

Abstract excerpt

BACKGROUND AND PURPOSE: The p53 tumor suppression pathway is important in effects associated with radiotherapy. The mouse double minute 2 (MDM2) plays a pivotal role in this pathway by down regulating p53. A functional T-to-G polymorphism at nucleotide 309 in MDM2 promoter intron 1 (SNP309) has been identified which influenced transcription activity. A G-to-C SNP at p53 codon 72 results in an Arg/Pro...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18423915
DOI: 10.1016/j.radonc.2008.03.018

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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