Article
Multiple sclerosis risk variants influence the peripheral B-cell compartment early in life in the general population.
European journal of neurology - 1 Feb 2023
de Mol Casper L, van Luijn Marvin M, Kreft Karim L, Looman Kirsten I M, van Zelm Menno C, White Tonya, Moll Henriette A, Smolders Joost, Neuteboom Rinze F
Abstract excerpt
BACKGROUND AND PURPOSE: Multiple sclerosis (MS) is associated with abnormal B-cell function, and MS genetic risk alleles affect multiple genes that are expressed in B cells. However, how these genetic variants impact the B-cell compartment in early childhood is unclear. In the current study, we aim to assess whether polygenic risk scores (PRSs) for MS are associated with changes in the blood B-cell compartment in...
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