Article
T cell composition and polygenic multiple sclerosis risk: A population-based study in children.
European journal of neurology - 1 Nov 2021
de Mol Casper L, Looman Kirsten I M, van Luijn Marvin M, Kreft Karim L, Jansen Philip R, van Zelm Menno C, Smolders Joost J F M, White Tonya J H, Moll Henriette A, Neuteboom Rinze F
Abstract excerpt
BACKGROUND AND PURPOSE: Patients with multiple sclerosis (MS) have altered T cell function and composition. Common genetic risk variants for MS affect proteins that function in the immune system. It is currently unclear to what extent T cell composition is affected by genetic risk factors for MS, and how this may precede a possible disease onset. Here, we aim to assess whether an MS polygenic risk score (PRS) is...
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