Article
Risk genes associated with pediatric-onset MS but not with monophasic acquired CNS demyelination.
Neurology - 3 Dec 2013
van Pelt E Daniëlle, Mescheriakova Julia Y, Makhani Nalia, Ketelslegers Immy A, Neuteboom Rinze F, Kundu Suman, Broer Linda, Janssens Cecile, Catsman-Berrevoets Coriene E, van Duijn Cornelia M, Banwell Brenda, Bar-Or Amit, Hintzen Rogier Q
Abstract excerpt
OBJECTIVE: To investigate whether 57 genetic risk loci recently identified in a large-scale genome-wide association study in adult patients with multiple sclerosis (MS) are also associated with a risk for pediatric-onset MS and whether they can predict MS diagnosis in children presenting with acquired demyelinating syndromes (ADS). METHODS: We included 188 children with ADS, of whom 53 were diagnosed with MS, 466...
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