Enhancing the BOADICEA cancer risk prediction model to incorporate new data on RAD51C, RAD51D, BARD1 updates to tumour pathology and cancer incidence.

doi:10.1136/jmedgenet-2022-108471

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Article

Enhancing the BOADICEA cancer risk prediction model to incorporate new data on RAD51C, RAD51D, BARD1 updates to tumour pathology and cancer incidence.

Journal of medical genetics - 1 Dec 2022

Lee Andrew, Mavaddat Nasim, Cunningham Alex, Carver Tim, Ficorella Lorenzo, Archer Stephanie, Walter Fiona M, Tischkowitz Marc, Roberts Jonathan, Usher-Smith Juliet, Simard Jacques, Schmidt Marjanka K, Devilee Peter, Zadnik Vesna, Jürgens Hannes, Mouret-Fourme Emmanuelle, De Pauw Antoine, Rookus Matti, Mooij Thea M, Pharoah Paul Pd, Easton Douglas F, Antoniou Antonis C

Abstract excerpt

BACKGROUND: BOADICEA (Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm) for breast cancer and the epithelial tubo-ovarian cancer (EOC) models included in the CanRisk tool (www.canrisk.org) provide future cancer risks based on pathogenic variants in cancer-susceptibility genes, polygenic risk scores, breast density, questionnaire-based risk factors and family history. Here, we...

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PMID: 36162851
DOI: 10.1136/jmedgenet-2022-108471
PMCID: PMC9691826

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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