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Article

Comprehensive epithelial tubo-ovarian cancer risk prediction model incorporating genetic and epidemiological risk factors.

Journal of medical genetics - 1 Jul 2022

Lee Andrew, Yang Xin, Tyrer Jonathan, Gentry-Maharaj Aleksandra, Ryan Andy, Mavaddat Nasim, Cunningham Alex P, Carver Tim, Archer Stephanie, Leslie Goska, Kalsi Jatinder, Gaba Faiza, Manchanda Ranjit, Gayther Simon, Ramus Susan J, Walter Fiona M, Tischkowitz Marc, Jacobs Ian, Menon Usha, Easton Douglas F, Pharoah Paul, Antoniou Antonis C

Abstract excerpt

BACKGROUND: Epithelial tubo-ovarian cancer (EOC) has high mortality partly due to late diagnosis. Prevention is available but may be associated with adverse effects. A multifactorial risk model based on known genetic and epidemiological risk factors (RFs) for EOC can help identify women at higher risk who could benefit from targeted screening and prevention. METHODS: We developed a multifactorial EOC risk model...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34844974
DOI: 10.1136/jmedgenet-2021-107904
PMCID: PMC9252860

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