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Enhancing the BOADICEA cancer risk prediction model to incorporate new data on <i>RAD51C, RAD51D, BARD1</i>, updates to tumour pathology and cancer incidences

2022-01-28

Abstract excerpt

<h4>Background</h4> BOADICEA for breast cancer and the epithelial ovarian cancer (EOC) models included in the CanRisk tool ( www.canrisk.org ) provide future cancer risks based on rare pathogenic variants in cancer-susceptibility genes, polygenic risk scores, breast-density, questionnaire-based risk factors and family history. Here, we extend the models to include the effects of pathogenic variants in recently est...

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Literature Corpus work
ac13ace7-0acd-54f7-8dd5-4608e27e45fb
DOI
10.1101/2022.01.27.22269825
Open publication

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Enhancing the BOADICEA cancer risk prediction model to incorporate new data on <i>RAD51C, RAD51D, BARD1</i>, updates to tumour pathology and cancer incidencesDOI 10.1101/2022.01.27.22269825
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