Article
Validation of the BOADICEA model for epithelial tubo-ovarian cancer risk prediction in UK Biobank.
British journal of cancer - 1 Nov 2024
Yang Xin, Wu Yujia, Ficorella Lorenzo, Wilcox Naomi, Dennis Joe, Tyrer Jonathan, Carver Tim, Pashayan Nora, Tischkowitz Marc, Pharoah Paul D P, Easton Douglas F, Antoniou Antonis C
Abstract excerpt
BACKGROUND: The clinical validity of the multifactorial BOADICEA model for epithelial tubo-ovarian cancer (EOC) risk prediction has not been assessed in a large sample size or over a longer term. METHODS: We evaluated the model discrimination and calibration in the UK Biobank cohort comprising 199,429 women (733 incident EOCs) of European ancestry without previous cancer history. We predicted 10-year EOC risk...
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