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Article

Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutations.

Neoplasia (New York, N.Y.) - 1 Nov 2022

Ha Dat P, Huang Bo, Wang Han, Rangel Daisy Flores, Van Krieken Richard, Liu Ze, Samanta Soma, Neamati Nouri, Lee Amy S

Abstract excerpt

KRAS is the most commonly mutated oncogene in human cancers with limited therapeutic options, thus there is a critical need to identify novel targets and inhibiting agents. The 78-kDa glucose-regulated protein GRP78, which is upregulated in KRAS cancers, is an essential chaperone and the master regulator of the unfolded protein response (UPR). Following up on our recent discoveries that GRP78 haploinsufficiency...

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Topics

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Share to Carcinogenesis
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Endoplasmic Reticulum Chaperone BiP

Share to Glucose

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Share to Proto-Oncogene Proteins p21(ras)

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 36162331
DOI: 10.1016/j.neo.2022.100837
PMCID: PMC9516447

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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