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Article

Roles of GRP78 in physiology and cancer

12 May 2010

Abstract excerpt

As one member of 70 kDa heat shock proteins, glucose-regulated protein 78 (GRP78) participates in protein folding, transportation and degradation. This sort of capacity can be enhanced by stresses under which GRP78 is induced rapidly. Unlike its homologues, GRP78 presents multifaceted subcellular position: When ER retention, it serves as the switch of unfolded protein response; When mitochondrial binding, it...

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PMID: 20506407
DOI: 10.1002/jcb.22679

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