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Article

Glucose-regulated protein 78 as a novel effector of BRCA1 for inhibiting stress-induced apoptosis.

Oncogene - 4 Dec 2008

Yeung B H Y, Kwan B W Y, He Q Y, Lee A S, Liu J, Wong A S T

Abstract excerpt

The tumor suppressor BRCA1 is mutated in a high percentage of familial breast and ovarian cancer, but our understanding of its mechanisms of action remains incomplete. We report here that glucose-regulated protein (GRP)-78, a critical regulator of the unfolded protein response (UPR), is a novel downstream target of BRCA1. We showed that overexpression of wild-type BRCA1 suppressed the expression of GRP78, whereas...

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Share to BRCA1 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18776923
DOI: 10.1038/onc.2008.290

Genes

BRCA1
GRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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