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Article

Endoplasmic reticulum chaperone GRP78/BiP is critical for mutant Kras-driven lung tumorigenesis.

Oncogene - 1 May 2021

Rangel Daisy Flores, Dubeau Louis, Park Ryan, Chan Priscilla, Ha Dat P, Pulido Mario A, Mullen Daniel J, Vorobyova Ivetta, Zhou Beiyun, Borok Zea, Offringa Ite A, Lee Amy S

Abstract excerpt

Lung cancer is the leading cause of cancer mortality worldwide and KRAS is the most commonly mutated gene in lung adenocarcinoma (LUAD). The 78-kDa glucose-regulated protein GRP78/BiP is a key endoplasmic reticulum chaperone protein and a major pro-survival effector of the unfolded protein response (UPR). Analysis of the Cancer Genome Atlas database and immunostain of patient tissues revealed that compared to...

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Identifiers

PMID: 33931739
DOI: 10.1038/s41388-021-01791-9
PMCID: PMC8179725

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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