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Cell surface GRP78 signaling: An emerging role as a transcriptional modulator in cancer

31 Aug 2020

Abstract excerpt

Cancer cells acquire dysregulated gene expression to establish specific transcriptional dependencies and their underlying mechanisms that are ultimately responsible for this addictions have not been fully elucidated. Glucose-regulated protein 78 (GRP78) is a stress-inducible, multifunctional, prosurvival, endoplasmic reticulum chaperone in the heat shock protein 70 family. Expression of cell surface GRP78...

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PMID: 32864780
DOI: 10.1002/jcp.30030

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