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Article

The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic BRAF Mutant Colorectal Cancer.

Molecular cancer therapeutics - 1 Jun 2018

Forsythe Nicholas, Refaat Alaa, Javadi Arman, Khawaja Hajrah, Weir Jessica-Anne, Emam Heba, Allen Wendy L, Burkamp Frank, Popovici Vlad, Jithesh Puthen V, Isella Claudio, Labonte Melissa J, Mills Ian G, Johnston Patrick G, Van Schaeybroeck Sandra

Abstract excerpt

BRAFV600E mutations occur in ∼10% of colorectal cancer cases, are associated with poor survival, and have limited responses to BRAF/MEK inhibition with or without EGFR inhibition. There is an unmet need to understand the biology of poor prognostic BRAFMT colorectal cancer. We have used differential gene expression and pathway analyses of untreated stage II and stage III BRAFMT (discovery set: n = 31; validation...

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Source

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Identifiers

PMID: 29483217
DOI: 10.1158/1535-7163.MCT-17-0603
PMCID: PMC5985931

Genes

BRAF
EGFR
HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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