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Article

Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress.

Molecular cancer therapeutics - 1 Mar 2016

Wang Chun Yan, Guo Su Tang, Wang Jia Yu, Liu Fen, Zhang Yuan Yuan, Yari Hamed, Yan Xu Guang, Jin Lei, Zhang Xu Dong, Jiang Chen Chen

Abstract excerpt

Oncogenic mutations of KRAS pose a great challenge in the treatment of colorectal cancer. Here we report that mutant KRAS colon cancer cells are nevertheless more susceptible to apoptosis induced by the HSP90 inhibitor AUY922 than those carrying wild-type KRAS. Although AUY922 inhibited HSP90 activity with comparable potency in colon cancer cells irrespective of their KRAS mutational statuses, those with mutant...

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Source

Identifiers

PMID: 26832792
DOI: 10.1158/1535-7163.MCT-15-0778

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress.PMID 26832792Read ↗

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