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Article

The critical role of GRP78/BiP MARylation in ER stress of KRAS-mutant colorectal cancer.

JCI insight - 23 Jan 2026

Zhang Shuxian, Chen Xiaodan, Gong Qian, Huang Jing, Tang Yi, Xiao Ming, Li Ming, Li Qingshu, Wang Yalan

Abstract excerpt

Nearly 50% of patients with KRAS-mutant colorectal cancer (CRC) currently lack effective targeted therapy. The accumulation of KRAS-mutant proteins can trigger a sustained high level of endoplasmic reticulum (ER) stress, and the UPR-based long-term protective regulatory pathway inhibits the aggregation of unfolded proteins, thereby maintaining the stability of the ER and enabling the continued survival of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41574609
DOI: 10.1172/jci.insight.182809
PMCID: PMC12892896

Genes

KRAS
ART1
ATF4
XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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