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Article

GRP 78‐mediated antioxidant response and ABC transporter activity confers chemoresistance to pancreatic cancer cells

8 May 2018

Abstract excerpt

Chemoresistance is a major therapeutic challenge that plays a role in the poor statistical outcomes in pancreatic cancer. Unfolded protein response (UPR) is one of the homeostasis mechanisms in cancer cells that have been correlated with chemoresistance in a number of cancers including pancreatic cancer. In this study, we show that modulating glucose regulatory protein 78 (GRP78), the master regulator of the UPR,...

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PMID: 29738634
DOI: 10.1002/1878-0261.12322

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