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Human sperm TMEM95 binds eggs and facilitates membrane fusion

26 Sept 2022

Abstract excerpt

knockout murine sperm can bind to, but do not fuse with, eggs. How TMEM95 plays a role in membrane fusion of sperm and eggs has remained elusive. Here, we utilize a sperm penetration assay as a model system to investigate the function of human TMEM95. We show that human TMEM95 binds to hamster egg membranes, providing evidence for a TMEM95 receptor on eggs. Using X-ray crystallography, we reveal an evolutionarily...

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PMID: 36161911
DOI: 10.1073/pnas.2207805119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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