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Subfertility in bulls carrying a nonsense mutation in transmembrane protein 95 is due to failure to interact with the oocyte vestments.

Biology of reproduction - 1 Jul 2017

Fernandez-Fuertes Beatriz, Laguna-Barraza Ricardo, Fernandez-Gonzalez Raul, Gutierrez-Adan Alfonso, Blanco-Fernandez Alfonso, O'Doherty Alan M, Di Fenza Mauro, Kelly Alan K, Kölle Sabine, Lonergan Patrick

Abstract excerpt

In a recent genome-wide association study, 40 Fleckvieh bulls with exceptionally poor fertility were found to be homozygous for a nonsense mutation in the transmembrane protein 95 (TMEM95) encoding gene. Ejaculates from these individuals exhibited normal sperm concentration, morphology, viability, and motility. However, only 1.7% of inseminations resulted in pregnancies. The aim of this study was to examine the...

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Identifiers

PMID: 28859280
DOI: 10.1093/biolre/iox065

Genes

TMEM95

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