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The cell biology of fertilization: Gamete attachment and fusion

17 Aug 2021

Abstract excerpt

Fertilization is defined as the union of two gametes. During fertilization, sperm and egg fuse to form a diploid zygote to initiate prenatal development. In mammals, fertilization involves multiple ordered steps, including the acrosome reaction, zona pellucida penetration, sperm-egg attachment, and membrane fusion. Given the success of in vitro fertilization, one would think that the mechanisms of fertilization...

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PMID: 34459848
DOI: 10.1083/jcb.202102146

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