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Article

Immune depletion of the methylated phenotype of colon cancer is closely related to resistance to immune checkpoint inhibitors.

Frontiers in immunology - 1 Jan 2022

Zhong Chengqian, Xie Tingjiang, Chen Long, Zhong Xuejing, Li Xinjing, Cai Xiumei, Chen Kaihong, Lan Shiqian

Abstract excerpt

Background: Molecular typing based on single omics data has its limitations and requires effective integration of multiple omics data for tumor typing of colorectal cancer (CRC). Methods: Transcriptome expression, DNA methylation, somatic mutation, clinicopathological information, and copy number variation were retrieved from TCGA, UCSC Xena, cBioPortal, FireBrowse, or GEO. After pre-processing and calculating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36159794
DOI: 10.3389/fimmu.2022.983636
PMCID: PMC9492852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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